Sildenafil Citrate Tablets

What are Sildenafil Citrate Tablets

Sildenafil citrate tablets are an oral prescription medication used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH) in men. Its core ingredient, sildenafil, works by inhibiting phosphodiesterase type 5 (PDE5).

Mechanism of Action

Sildenafil is a selective inhibitor of PDE5. During sexual stimulation, the corpus cavernosum releases nitric oxide (NO), which activates guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) levels. This leads to relaxation of vascular smooth muscle and increased blood flow, thus inducing an erection. PDE5 breaks down cGMP, and sildenafil inhibits PDE5, reducing cGMP degradation and maintaining corpus cavernosum vasodilation, enhancing erectile function. Without sexual stimulation, the drug will not actively induce an erection.

Indications

Erectile Dysfunction (ED):
Indicated for erectile dysfunction due to psychological, vascular, or neurological factors. It should be used only after the cause of ED is identified, such as in patients with diabetes, hypertension, or post-prostate surgery.
Pulmonary Arterial Hypertension (PAH):
It reduces blood pressure by dilating pulmonary blood vessels, improving exercise tolerance and slowing disease progression. Long-term treatment is required, and the dosage differs from that for ED.

How it works

When a man experiences sexual stimulation, the blood vessels in his penis release a chemical called nitric oxide (NO).

Nitric oxide triggers the production of another substance in the body, cyclic guanosine monophosphate (cGMP). cGMP relaxes the smooth muscle of the corpus cavernosum, increasing arterial blood flow and triggering an erection.

An enzyme in the body called PDE5 breaks down cGMP, causing erections to subside.

Sildenafil works by inhibiting PDE5, reducing the breakdown of cGMP. This helps maintain elevated cGMP levels during sexual stimulation and enhances erectile function.

Dosage and Administration

Time of Use: Typically, take the drug approximately 30 minutes to 1 hour before sexual activity. Taking the drug after eating (especially with fatty foods) may delay absorption and prolong its effect.

Dosage:

A common starting dose is 50 mg.

Based on your response and tolerance, your doctor may adjust the dose to 25 mg (for less effective but well tolerated) or to 100 mg (for effective and well tolerated).

Use up to once daily.

Onset and Duration of Effect: The drug begins to work approximately 30-60 minutes after taking it, and its effects typically last 4-6 hours. During this time, an erection is possible with sexual stimulation.

Benefits of Sildenafil Citrate Tablets

1. Effective and Reliable Physiological Improvement
Restores Natural Erectile Function: Sildenafil increases penile blood flow, helping men achieve and maintain a firm erection during sexual stimulation. It is not an aphrodisiac, but rather works to restore normal physiological responses.

High Success Rate: As the first PDE5 inhibitor to be marketed, it has extensive clinical data supporting its effectiveness for most types of ED (psychogenic, organic, and mixed).

Long Window of Action: The drug's effects last for 4-6 hours, providing a longer window of flexibility and helping to alleviate the anxiety associated with time pressure.

2. Significantly Improves Mental Health and Self-Confidence
ED is not only a physical problem; it also has a significant psychological impact on men.

Restores Confidence: Successful treatment can significantly restore a man's sexual confidence and break the vicious cycle of performance anxiety.

Relieves Anxiety and Stress: Worry and fear about sex are significant factors that exacerbate ED. Effective treatment can significantly alleviate this psychological burden.

Improves overall mood: Improved sexual health is often associated with greater life satisfaction and more positive moods.

3. Improves relationships and quality of life: Sexual activity is an important component of intimate relationships.

Enhances intimacy: Successful sexual activity can enhance emotional connection, closeness, and communication between couples.

Relieves stress for partners: ED often causes stress and misunderstanding for both partners. Effective treatment can help alleviate relationship strain and restore a satisfying sex life.

Improves overall quality of life: Viewing ED as a treatable medical condition, rather than a personal flaw, can help men and their partners enjoy a fuller, higher-quality life.

Storage conditions

Room temperature (20–25°C), protected from light, moisture, and sealed, keep out of reach of children

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