Product Details
"Sildenafil for Pulmonary Hypertension" refers to the use of sildenafil to treat pulmonary arterial hypertension (PAH). This medication dilates pulmonary blood vessels and reduces pulmonary artery pressure, thereby improving heart function and exercise tolerance.
Basic Definition
Pulmonary Arterial Hypertension (PAH) is a serious cardiopulmonary disease characterized by abnormal constriction, thickening, or hardening of the pulmonary arteries, which impedes blood flow through the lungs and increases the workload on the heart's right ventricle. Long-term effects may lead to right heart failure.
Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, was originally used to treat erectile dysfunction (ED) in men. However, it was later discovered that it can also dilate pulmonary blood vessels and reduce pulmonary artery pressure through a similar mechanism.
Mechanism of Action
Sildenafil inhibits the PDE5 enzyme. The activity of Sildenafil (Sildenafil) increases cGMP (cyclic guanosine monophosphate) levels in the body.
Increased cGMP can:
Relax pulmonary vascular smooth muscle
Reduce pulmonary arterial pressure
Relieve right ventricular overload
Improve blood oxygenation and exercise tolerance
Simply put:
It relaxes the pulmonary blood vessels, allowing blood flow to flow more smoothly and the heart to relax.
Instructions:
Sildenafil 20 mg tablets: 20 mg three times daily (approximately every 8 hours) orally, can be taken with or without food.
Indications
Indicated for the treatment of pulmonary arterial hypertension (PAH) in adults and children.
It is particularly suitable for patients with WHO functional class II–III (i.e., mild to moderate symptoms).
Clinical Benefits
Significantly reduces pulmonary arterial pressure
Improves exercise tolerance and dyspnea (e.g., increases 6-minute walk distance)
Delays disease progression and improves quality of life
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