Dapoxetine 30mg

Dapoxetine 30mg is the world's first oral medication specifically designed for premature ejaculation (PE). By targeting the activity of the brain's serotonin (5-HT) transporter, it significantly prolongs intravaginal ejaculatory latency time (IELT), helping men achieve a controlled, lasting, and pleasurable sexual experience. This product utilizes patented sustained-release technology, resulting in rapid onset and rapid metabolism. It is suitable for on-demand use in adult men aged 18-64.

Active ingredient: Each tablet contains 30mg of dapoxetine hydrochloride (equivalent to 28.5mg of dapoxetine).
Mechanism of Action: Selectively inhibits serotonin reuptake, enhances 5-HT concentrations in the synaptic cleft, activates the brain's ejaculatory control center, and delays the ejaculatory reflex. Clinical studies have shown that a single 30mg dose can prolong IELT by an average of 2.5-3 times without affecting libido or erectile function.

Core Indications: Adult men diagnosed with premature ejaculation (IELT < 2 minutes, poor ejaculation control), particularly those with premature ejaculation caused by psychological stress, nervousness, or mild organic factors.
Combination Use: Can be used with PDE5 inhibitors such as sildenafil (with at least a one-hour interval between use) to simultaneously address both erectile dysfunction and premature ejaculation.
Unsuitable Uses: Contraindicated for non-PE patients, women, adolescents under 18, and those allergic to any of the ingredients. Patients with severe cardiovascular disease, hepatic or renal impairment, or epilepsy should consult a physician before use.

Dosage: Take one tablet orally 1-3 hours before sexual activity with 250ml of warm water. Avoid high-fat foods and alcohol (which may delay the drug's effect).
Dose Adjustment: Starting dose: 30mg. If insufficient effect and good tolerance are achieved, the dose can be increased to 60mg (as directed by a physician). Only one dose per 24-hour period is recommended. Dosage should not exceed 60mg. Treatment Recommendation: Use as needed, with 8-12 weeks of continuous use recommended to consolidate results. Combining with behavioral therapy (such as stop-and-go maneuvers and Kegel exercises) offers optimal results.

Contraindications: Concomitant use with monoamine oxidase inhibitors (MAOIs), SSRIs, and strong CYP3A4 inhibitors (such as ketoconazole) is contraindicated. This product is contraindicated in patients with moderate to severe liver impairment, heart block, or epilepsy.
Common Side Effects: Mild nausea (approximately 5%), dizziness (3%), and headache (2%), usually resolving within 2 hours. Rare side effects include insomnia, diarrhea, and orthostatic hypotension.
Safety Monitoring: Monitor blood pressure and heart rate upon first use. Avoid taking this product before driving or operating machinery (it may cause transient dizziness).

Chemical Composition and Structure
Chemical Name: (±)-N,N-Dimethyl-1-[3-(naphthalen-1-yloxy)propyl]propan-2-amine hydrochloride, Molecular Formula: C₂₁H₂₃NO·HCl, Molecular Weight: 341.88, pKa: 8.6 (ionic under physiological conditions).
Physical Properties: White to off-white crystalline powder, water-soluble, Density: 1.081 g/cm³, Boiling Point: 454.4°C, Flash Point: 132.6°C.
Structural Features: A selective serotonin reuptake inhibitor (SSRI), it contains no halogen atoms and a naphthyl structure, similar to fluoxetine but with a unique naphthoxy side chain.

Mechanism of Action
Core Principle: By selectively inhibiting the serotonin transporter (SERT), it blocks the reuptake of serotonin (5-HT) by presynaptic neurons, increasing 5-HT concentrations in the synaptic cleft and enhancing the activity of ejaculation control centers (such as the spinal ejaculatory reflex center), thereby prolonging the intravaginal ejaculation latency time (IELT).
Secondary Effects: At high concentrations, it inhibits dopamine reuptake and also has a mild inhibitory effect on the norepinephrine transporter, synergistically enhancing the delaying effect.
Neuromodulatory Effects: By regulating the brain's 5-HT system, it improves ejaculatory control and reduces anxiety-related premature ejaculation symptoms.

Pharmacokinetics
Absorption: Rapidly absorbed after oral administration, with peak time (Tmax) of approximately 1.3 hours and bioavailability of approximately 42% (fasting). A high-fat diet may slightly delay absorption but does not affect overall exposure.
Distribution: Plasma protein binding is >99%, with a steady-state volume of distribution of approximately 162 L, and widespread tissue distribution. Metabolism: Primarily metabolized by hepatic CYP2D6, CYP3A4, and flavin-containing monooxygenase (FMO1), producing metabolites such as desmethyldapoxetine (equivalent in activity to the parent drug). The half-life is approximately 19 hours, and the 24-hour plasma concentration decreases to less than 5% of the peak value.

Excretion: Metabolites are primarily excreted in the urine, with minimal renal excretion of the parent drug.

Our Payment Methods

 

 

Hot Tags: dapoxetine 30mg, China dapoxetine 30mg manufacturers, suppliers